Association of anti-thyroid peroxidase antibody among Euthyroid women with adverse pregnancy outcomes

Document Type : Original Article

Authors

Prenatal Diagnosis and Fetal Medicine Department, Human Genetics and Genome Research Institute, National Research Centre. Cairo, Egypt.

Abstract

ABSTRACT



Background: Thyroid autoimmunity (TAI) can have an adverse impact on pregnancy outcomes. Thyroid peroxidase (TPO) is a main enzyme needed in thyroid hormones; important autoantigen in autoimmune thyroid diseases.

Methods: It is a prospective study . 250 women in euthyroid state were screened for positive existence of anti-TPO Ab. 40 out of 250 were positive for anti TPO antibodies. Those 40 Euthyroid pregnant females were observed , and outcomes were compared to gestation matched controls pregnant women (anti-TPO negative) using Elisa.

Results: Anti-TPO positivity among screened pregnant women was 16%. Anti-TPO positive, euthyroid females had a higher occurrence of pregnancy loss 22.5 % vs. 5%; p<0.05, preterm labor 25% vs. 7.5%; p<0.05. Pregnant women positive for anti-TPO Ab had higher risk for pregnancy loss (5 folds) and for preterm labor (4 folds ) in comparison to the control .

Conclusion: There is correlation between the presences of anti-TPO antibodies among pregnant women with adverse pregnancy outcomes in euthyroid state pregnant women.

Keywords

Middle East Journal of Medical Genetics

Articles in Press, Accepted Manuscript
Available Online from 27 February 2024

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